* [[Beta blockers]]—evidence from controlled trials spanning 25 years supports the claim that beta-blockers are effective for reducing anxiety, likely through peripheral blockade of beta-receptors; most data comes from studies of generalized anxiety and acute stress.{{Cite journal|author=Tyrer P |title=Anxiolytics not acting at the benzodiazepine receptor: beta blockers. |journal=Prog Neuropsychopharmacol Biol Psychiatry |volume=16 |issue=1 |pages=17–26 |date=January 1992 |pmid=1348368 |doi=10.1016/0278-5846(92)90004-X}} * [[Theanine]]relaxation; found in [[Green tea extract|green tea]]; increases nicotinic acetylcholine and reduces nicotinic dopamine {{Citation needed|date=February 2014}} * [[Lemon Balm]]—displays adaptogen properties; in rats it has been shown to possess [[GABA transaminase inhibitor]] activity{{Cite journal|author=Awad, R.; Levac, D.; Cybulska, P.; Merali, Z.; Trudeau, V.L.; Arnason, J.T. |title=Effects of traditionally used anxiolytic botanicals on enzymes of the γ-aminobutyric acid (GABA) system |journal=Can J Physiol Pharmacol. |volume=85 |issue=9 |pages=933–42 |date=September 2007 |pmid=18066140 |doi=10.1139/Y07-083}} and in homogenates of human cerebral cortical cell membranes possesses activity at [[acetylcholine receptors]].{{Cite journal|author=Wake G, Court J, Pickering A, Lewis R, Wilkins R, Perry E |title=CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory |journal=J Ethnopharmacol. |volume=69 |issue=2 |pages=105–14 |date=February 2000 |pmid=10687867 |doi=10.1016/S0378-8741(99)00113-0}} In a randomized, double-blind, placebo-controlled study of 18 healthy volunteers, 600 mg of '[[Melissa officinalis]]' extract attenuated volunteers' response to a laboratory-induced stress test 1 hour after administration; 300 mg significantly improved speed of mathematical processing 1 hour after administration.{{Cite journal|author=Kennedy DO, Little W, Scholey AB |title=Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm) |journal=Psychosom Med. |volume=66 |issue=4 |pages=607–13 |date=Jul–Aug 2004 |pmid=15272110 |doi=10.1097/01.psy.0000132877.72833.71}} * [[Passion Flower]]—possible [[MAOI]] and neurotransmitter reuptake activity {{Citation needed|date=February 2011}} * [[Rhodiola Rosea]]—adaptogen; possible MAOI activityPanossian A., Wikman G."Evidence based efficacy of adaptogens in fatigue" ''[[Planta Medica]]'' 2009; 75:9 * [[St John's Wort]]—herbal supplement approved (in Europe) to treat mild depression. Method of action is unproven but exhibits effects similar to both MAOIs and SSRIs. {{Citation needed|date=February 2011}} There is evidence that it may decrease the effectiveness of methylphenidate treatment.{{cite pmid|17254717}} * [[Ginseng]] (including [[Siberian ginseng]])—adaptogenic effects shown{{Citation needed|date=February 2011}} * [[Sutherlandia frutescens]]—possible anti-inflammatory, reducing pain from those illnesses {{Citation needed|date=February 2011}} * [[Kava]]—anxiolytic herb{{Citation needed|date=February 2011}} * [[Grape seed extract]]—has shown some efficacy in reducing bodily stress{{Citation needed|date=February 2011}} * [[Adafenoxate]]—possible anxiolytic effect{{Citation needed|date=February 2011}} * [[Phenibut]] GABA receptor agonist excerting anxiolytic effects * [[Picamilon]] GABA prodrug which excerts anxiolytic effects by releasing GABA and niacin in the CNS. * [[Valerian (herb)|Valerian]]—possible anxiolytic effect through agonism at [[GABA-A]] receptors{{Citation needed|date=February 2011}} * [[Butea frondosa]]—possible anxiolytic effect{{Cite journal|author=Soman I, Mengi SA, Kasture SB |title=Effect of leaves of ''Butea frondosa'' on stress, anxiety, and cognition in rats |journal=Pharmacol. Biochem. Behav. |volume=79 |issue=1 |pages=11–6 |date=September 2004 |pmid=15388278 |doi=10.1016/j.pbb.2004.05.022}}